Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.81 |
| ▸ | LMNA | P02545 | 5/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.81 |
| ▸ | PGR | P06401 | 5/20 | 0.81 |
| ▸ | AR | P10275 | 3/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178133 | 1.00 | NR3C1 (0.81) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL24622359 | 1.00 | NR3C1 (0.81) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL11436422 | 0.94 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL24622511 | 0.94 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL7899994 | 0.94 | NR3C1 (0.85) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL11733697 | 0.92 | NR3C1 (0.82) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL13178082 | 0.91 | NR3C1 (0.71) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL8205284 | 0.91 | NR3C1 (0.86) | NR3C1LMNAHIF1APGRAR | |
| SCHEMBL6324045 | 0.90 | NR3C1 (0.80) | NR3C1LMNAHIF1APGRAR | |
| Fluocinolone Acetonide SCHEMBL4116560 | 0.90 | NR3C1 (1.00) | NR3C1LMNAHIF1APGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108118-A9 | 16 ALPHA, 17 ALPHA-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES AND THEIR USE | ASTRAZENECA AB (SE) | 2010-09-02 | — | — | WO | disclosed |
| WO-2009108118-A1 | 16 ALPHA, 17 ALPA-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES AND THEIR USE | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | WO | disclosed |