Isoxazole

Isoxazole

SCHEMBL1318

c1cnoc1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoxazole SCHEMBL2679369 1.00 PARP1 (1.00)
Isoxazole SCHEMBL393230 1.00
Isoxazole SCHEMBL31018965 0.96
Isoxazole SCHEMBL2106061 0.96
Isoxazole SCHEMBL30791001 0.96
Isoxazole SCHEMBL1312467 0.96
Isoxazole SCHEMBL1798124 0.96
Isoxazole SCHEMBL1118550 0.96
Isoxazole SCHEMBL21448373 0.96
Isoxazole SCHEMBL9491120 0.96

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 144367 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146049-A1 SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2026-05-28 US claimed
US-20260144788-A1 COMPOUND FOR SHP2 PROTEIN DEGRADATION AND MEDICAL USES THEREOF UBIX THERAPEUTICS, INC. (KR) 2026-05-28 US claimed
US-20260146050-A1 KRAS DEGRADING COMPOUNDS COMPRISING SPIROCYCLIC ANNULATED 2 AMINO-3-CYANO THIOPHENES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2026-05-28 US claimed
CN-122079918-A Isoxazole biphenyl compounds with CBP BRD and BRD4 BD2 inhibitory activity, and preparation method and application thereof 2026-05-26 CN claimed
CN-116854681-B Hormone receptor modulators for the treatment of metabolic conditions and disorders ARDELYX, INC. (US) 2026-05-26 CN claimed
CN-122094940-A Ionizable lipids and uses thereof 2026-05-26 CN claimed
CN-122076982-A Graphite alkyne/gold nanocomposite and preparation method and application thereof 2026-05-26 CN claimed
US-20260137650-A1 MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) 11949098 CANADA INC (CA) 2026-05-21 US claimed
WO-2026106499-A1 OREXIN RECEPTOR ANTAGONISTS: 2-AZABICYCLIC COMPOUNDS BIAL - PORTELA & CA., S.A. (PT) 2026-05-21 WO claimed
EP-4743120-A1 MOLECULAR DEGRADERS FOR THE TREATMENT OF IGA NEPHROPATHY Biohaven Therapeutics Ltd. (VG) 2026-05-20 EP claimed
US-4028323-A WITH A SUBSTITUTED AMINOBENZENE CIBA-GEIGY AG (CH) 1977-06-07 US claimed
US-4022797-A PHARMACEUTICALS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-10 US claimed
US-4021245-A GELATION DERIVATIVE, SILICIC ACID ANHYDRIDE FUJI PHOTO FILM CO., LTD. (JA) 1977-05-03 US claimed
US-4013769-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-03-22 US claimed
US-4000150-A HEAT EXCHANGE MEDIA, SURFACTANTS PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1976-12-28 US claimed
US-3993646-A Process for the ring expansion of penicillins to cephalosporin compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-11-23 US claimed
US-3984427-A Preparation of vinyl lactones and corresponding Mannich bases HOFFMANN-LA ROCHE INC. (US) 1976-10-05 US claimed
US-3964905-A Color photograhic material having a bleach inhibitor therein defining a sound track FUJI PHOTO FILM CO., LTD. (JA) 1976-06-22 US claimed
US-3940271-A SILVER HALIDE EMULSION, 2-ALKYLMERCAPTO-IMIDAZOLINE FUJI PHOTO FILM CO., LTD. (JA) 1976-02-24 US claimed
US-3936445-A FROM ISOXAZOLE, AN O-PHENYLENEDIAMINE AND AN IRON COMPOUND BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1976-02-03 US claimed