Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 10/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCH | P24723 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1317528 | 0.90 | DNM1 (0.53) | DNM1HSP90AA1RAD52HTTKMT2A | |
| SCHEMBL12120080 | 0.89 | DNM1 (0.44) | DNM1HSP90AA1RAD52HTTKMT2A | |
| Bromide SCHEMBL1320796 | 0.84 | DNM1 (0.50) | DNM1HSP90AA1RAD52HTTKMT2A | |
| Bromide SCHEMBL1316441 | 0.84 | DNM1 (0.50) | DNM1HSP90AA1RAD52HTTKMT2A | |
| Bromide SCHEMBL1319377 | 0.84 | DNM1 (0.50) | DNM1HSP90AA1RAD52HTTKMT2A | |
| Iodide SCHEMBL1320407 | 0.82 | PRKD3 (0.56) | DNM1HSP90AA1RAD52HTTKMT2A | |
| Iodide SCHEMBL1321524 | 0.82 | PRKD3 (0.56) | DNM1HSP90AA1RAD52HTTKMT2A | |
| Iodide SCHEMBL1316451 | 0.82 | PRKD3 (0.56) | DNM1HSP90AA1RAD52HTTKMT2A | |
| Iodide SCHEMBL1316828 | 0.82 | PRKD3 (0.56) | DNM1HSP90AA1RAD52HTTKMT2A | |
| SCHEMBL4875783 | 0.81 | CES1 (0.57) | HTTKMT2ACES1CES2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269652-A1 | GEMINI SURFACTANTS | ST. FRANCIS XAVIER UNIVERSITY (CA) | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269652-A1 | GEMINI SURFACTANTS | SGMS1, DEGS1, GMNN | DNM1 2074/4885HSP90AA1 3009/4885RAD52 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.