Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA3 | P42263 | 1/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 11/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107107 | 0.85 | GRIA3 (0.56) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7897196 | 0.84 | GRIA3 (0.52) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7884908 | 0.81 | GRIA3 (0.54) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL548685 | 0.77 | GRIA3 (0.49) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8107156 | 0.74 | GRIA3 (0.58) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8114062 | 0.74 | GRIA3 (0.48) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL548617 | 0.74 | GRIA3 (0.53) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13183222 | 0.73 | GRIA3 (0.47) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8105521 | 0.72 | GRIA3 (0.59) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL637281 | 0.72 | GRIA3 (0.55) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233140-A1 | Bicyclic amides for enhancing glutamatergic synaptic responses | Biovail Laboratories International SRL (BB) | 2010-09-29 | — | — | EP | disclosed |