Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884908 | 0.87 | GRIA3 (0.54) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13183174 | 0.84 | GRIA3 (0.48) | GRIA3GRIA4CCNCCDK8EPHX2 | |
| SCHEMBL8107156 | 0.78 | GRIA3 (0.58) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| Cx-717 SCHEMBL243542 | 0.76 | GRIA3 (0.76) | GRIA3GRIA4HPGDHTTALDH1A1 | |
| SCHEMBL8105521 | 0.76 | GRIA3 (0.59) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL638015 | 0.75 | GRIA3 (0.57) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL8107107 | 0.73 | GRIA3 (0.56) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL8105886 | 0.73 | GRIA3 (0.52) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL637281 | 0.73 | GRIA3 (0.55) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL8114056 | 0.71 | GRIA3 (0.50) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010087980-A2 | BICYCLIC AMIDE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DEPRESSION | CORTEX PHARMACEUTICALS, INC. (US) | 2010-08-05 | — | — | WO | disclosed |