Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | FABP6 | P51161 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044923 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1L3MBTL1FABP6GAA | |
| SCHEMBL13160450 | 0.78 | DHODH (0.42) | KDM4EALDH1A1L3MBTL1FABP6GAA | |
| SCHEMBL31595636 | 0.71 | FABP6 (0.43) | KDM4EALDH1A1L3MBTL1FABP6NPY5R | |
| SCHEMBL769330 | 0.68 | FABP6 (0.58) | KDM4EALDH1A1L3MBTL1FABP6NPC1 | |
| SCHEMBL8025112 | 0.68 | FABP6 (0.50) | KDM4EALDH1A1L3MBTL1FABP6GAA | |
| SCHEMBL10508276 | 0.68 | FABP6 (0.50) | KDM4EALDH1A1L3MBTL1FABP6GAA | |
| SCHEMBL10434491 | 0.68 | KDM4E (0.51) | KDM4EALDH1A1L3MBTL1FABP6GAA | |
| SCHEMBL6560819 | 0.68 | KDM4E (0.62) | KDM4EALDH1A1L3MBTL1FABP6GAA | |
| SCHEMBL6560814 | 0.68 | KDM4E (0.62) | KDM4EALDH1A1L3MBTL1FABP6GAA | |
| SCHEMBL25937556 | 0.68 | KDM4E (0.62) | KDM4EALDH1A1L3MBTL1FABP6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795272-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICAL, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | disclosed |