Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.82 |
| ▸ | KDR | P35968 | 19/20 | 0.82 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | FPR1 | P21462 | 1/20 | 0.63 |
| ▸ | FPR3 | P25089 | 1/20 | 0.63 |
| ▸ | GPR183 | P32249 | 1/20 | 0.63 |
| ▸ | SMO | Q99835 | 1/20 | 0.63 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3568440 | 0.99 | MET (0.81) | METKDRFLT1FLT4AURKA | |
| SCHEMBL13185292 | 0.94 | MET (0.85) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3621972 | 0.93 | MET (0.84) | METKDRFLT1FLT4AURKA | |
| Hydrochloric Acid SCHEMBL3565404 | 0.93 | MET (0.84) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3622152 | 0.90 | MET (0.80) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3563620 | 0.90 | MET (1.00) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3616406 | 0.90 | MET (0.79) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3621597 | 0.89 | MET (0.89) | METKDRFLT1FLT4AURKA | |
| SCHEMBL3572217 | 0.88 | MET (0.82) | METKDRAURKAFPR1FPR3 | |
| SCHEMBL3610940 | 0.87 | MET (0.74) | METKDRFLT1FLT4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790729-B2 | Inhibitors of VEGF receptor and HGF receptor signaling | METHYLGENE INC. (CA) | 2010-09-07 | — | — | US | disclosed |