Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187520 | 1.00 | DHODH (0.43) | DHODHP2RX1HTTSMN1; SMN2RAF1 | |
| SCHEMBL13187341 | 1.00 | DHODH (0.43) | DHODHP2RX1HTTSMN1; SMN2RAF1 | |
| SCHEMBL13187528 | 0.93 | HTT (0.48) | DHODHHTTSMN1; SMN2 | |
| SCHEMBL1726200 | 0.90 | RAF1 (0.42) | RAF1PIK3CGMAPTTSHRNPY5R | |
| SCHEMBL1034121 | 0.83 | P2RX1 (0.43) | P2RX1HTTMCHR1ALDH1A1GAA | |
| SCHEMBL13187587 | 0.82 | PLG (0.46) | HTTSMN1; SMN2RAF1MAPT | |
| SCHEMBL13187196 | 0.80 | ABL1 (0.48) | DHODHP2RX1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13187141 | 0.79 | RAF1 (0.47) | RAF1MAPT | |
| SCHEMBL13187145 | 0.79 | RAF1 (0.40) | RAF1PIK3CGALDH1A1ALOX15TSHR | |
| SCHEMBL13187647 | 0.79 | GRM5 (0.36) | DHODHRAF1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |