Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13187665 | 1.00 | GRM5 (0.36) | GRM5CCNCCDK8PIM1DHODH | |
| SCHEMBL13187148 | 0.80 | RAF1 (0.40) | RAF1 | |
| SCHEMBL13187149 | 0.80 | RAF1 (0.40) | RAF1 | |
| SCHEMBL13187520 | 0.79 | DHODH (0.43) | DHODHRAF1PIK3CG | |
| SCHEMBL13187528 | 0.79 | HTT (0.48) | DHODHGSK3AGSK3BABL1 | |
| SCHEMBL13187547 | 0.79 | DHODH (0.43) | DHODHRAF1PIK3CG | |
| SCHEMBL13187341 | 0.79 | DHODH (0.43) | DHODHRAF1PIK3CG | |
| SCHEMBL13187650 | 0.79 | ALOX15 (0.39) | CCNCCDK8GSK3AGSK3BRAF1 | |
| SCHEMBL13187649 | 0.77 | RAF1 (0.39) | NTRK1RAF1 | |
| SCHEMBL13187920 | 0.73 | SIRT2 (0.48) | DHODHGSK3AGSK3BIRAK4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |