Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 15/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.41 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.41 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188206 | 0.93 | PIK3CG (0.52) | PIK3CGPIK3CAPIK3CDABL1ITK | |
| SCHEMBL13189183 | 0.93 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CDABL1ITK | |
| SCHEMBL13188213 | 0.90 | PIK3CD (0.49) | PIK3CGPIK3CAPIK3CDABL1 | |
| SCHEMBL13188327 | 0.90 | PIK3CG (0.65) | PIK3CGPIK3CAPIK3CDABL1MTOR | |
| SCHEMBL13188906 | 0.87 | PIK3CD (0.51) | PIK3CGPIK3CAPIK3CDABL1MTOR | |
| SCHEMBL13188907 | 0.87 | PIK3CG (0.50) | PIK3CGPIK3CAPIK3CDABL1 | |
| SCHEMBL13188342 | 0.86 | PIK3CD (0.49) | PIK3CGPIK3CAPIK3CDABL1PIK3R1 | |
| SCHEMBL13188338 | 0.86 | PIK3CG (0.54) | PIK3CGPIK3CAPIK3CDABL1ITK | |
| SCHEMBL3707116 | 0.84 | PIK3CD (0.51) | PIK3CGPIK3CAPIK3CDABL1ITK | |
| SCHEMBL13188326 | 0.83 | PIK3CG (0.66) | PIK3CGPIK3CAPIK3CDABL1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |