Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.52 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | CASP9 | P55211 | 1/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984551 | 0.83 | DGAT1 (0.72) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL9984784 | 0.83 | DGAT1 (0.65) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL9984615 | 0.80 | DGAT1 (0.69) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL12045654 | 0.78 | DGAT1 (0.64) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL12045653 | 0.78 | DGAT1 (0.63) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL12045663 | 0.75 | DGAT1 (0.62) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL9985119 | 0.75 | DGAT1 (0.63) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL9985189 | 0.75 | DGAT1 (0.64) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL9984246 | 0.75 | DGAT1 (0.70) | DGAT1SOAT2CYP2C9SOAT1DGAT2 | |
| SCHEMBL9984767 | 0.74 | DGAT1 (0.73) | DGAT1SOAT2CYP2C9SOAT1DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010107765-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |