Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.82 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.72 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.72 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275203 | 0.91 | TRPA1 (0.80) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10275117 | 0.90 | TRPA1 (1.00) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10275149 | 0.89 | TRPA1 (0.85) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10275419 | 0.89 | TRPA1 (0.83) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL14227825 | 0.88 | TRPA1 (0.79) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10275146 | 0.85 | TRPA1 (0.85) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10275058 | 0.84 | TRPA1 (0.89) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10275843 | 0.84 | TRPA1 (0.82) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL9933055 | 0.84 | TRPA1 (1.00) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL10275591 | 0.83 | TRPA1 (0.78) | TRPA1TRPV4TRPV3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109329-A1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |