Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076339 | 0.81 | ALDH1A1 (0.43) | MPLALDH1A1RAB9AALOX5LTA4H | |
| SCHEMBL12292215 | 0.75 | MPL (0.38) | MPLALDH1A1RAB9AALOX5LTA4H | |
| SCHEMBL12293459 | 0.67 | MPL (0.39) | MPLALDH1A1RAB9AALOX5LTA4H | |
| SCHEMBL12292213 | 0.66 | ALDH1A1 (0.36) | MPLALDH1A1RAB9AALOX5MEN1 | |
| SCHEMBL10719025 | 0.63 | ALDH1A1 (0.61) | MPLALDH1A1RAB9AALOX5LTA4H | |
| SCHEMBL20390649 | 0.62 | ALDH1A1 (0.44) | ALDH1A1RAB9AALOX5LTA4HMEN1 | |
| SCHEMBL474185 | 0.61 | MPL (0.60) | MPLALDH1A1RAB9AALOX5LTA4H | |
| SCHEMBL1801097 | 0.61 | MPL (0.65) | MPLALDH1A1RAB9AALOX5LTA4H | |
| SCHEMBL245790 | 0.61 | SMN1; SMN2 (0.44) | MPLALDH1A1RAB9AALOX5LTA4H | |
| SCHEMBL1800446 | 0.60 | MPL (0.59) | MPLALDH1A1RAB9AALOX5LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109329-A1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |