Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.60 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13189815 | 0.97 | TRPA1 (0.60) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL13189597 | 0.89 | TRPA1 (0.61) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL13189817 | 0.88 | TRPA1 (0.76) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL13189816 | 0.87 | TRPA1 (0.63) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL10275253 | 0.86 | TRPA1 (0.79) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL13189598 | 0.86 | TRPA1 (0.61) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL13189596 | 0.86 | TRPA1 (0.52) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL13190002 | 0.85 | TRPA1 (0.61) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL10275153 | 0.83 | TRPA1 (0.79) | TRPA1TRPV4TRPV1TRPV3 | |
| SCHEMBL13190009 | 0.81 | TRPA1 (0.60) | TRPA1TRPV4TRPV1TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109329-A1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |