Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13190274 | 0.90 | DGAT1 (0.60) | DGAT1HTR2AHTR2CHTR2B | |
| SCHEMBL10198285 | 0.89 | DGAT1 (0.65) | DGAT1RIPK1HTR2AHTR2CLMNA | |
| SCHEMBL410376 | 0.88 | DGAT1 (0.79) | DGAT1RIPK1 | |
| SCHEMBL410375 | 0.88 | DGAT1 (0.79) | DGAT1RIPK1 | |
| SCHEMBL13190607 | 0.86 | DGAT1 (0.77) | DGAT1HTR2AHTR2CPKMSMN1; SMN2 | |
| SCHEMBL13190423 | 0.86 | DGAT1 (0.62) | DGAT1HTR2AHTR2CLMNAMAPT | |
| SCHEMBL13190476 | 0.84 | DGAT1 (0.61) | DGAT1HTR2AHTR2CMAPTPKM | |
| SCHEMBL13190422 | 0.83 | DGAT1 (0.63) | DGAT1HTR2AHTR2CMAPTPKM | |
| SCHEMBL13190617 | 0.82 | DGAT1 (0.79) | DGAT1HTR2AHTR2CLMNAMAPT | |
| SCHEMBL13190276 | 0.80 | DGAT1 (0.51) | DGAT1HTR2AHTR2CSMN1; SMN2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010107768-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |