Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.55 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10260804 | 0.75 | DGAT1 (0.76) | DGAT1SOAT2SMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL13190398 | 0.71 | DGAT1 (0.61) | DGAT1SOAT2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL409495 | 0.71 | DGAT1 (1.00) | DGAT1SOAT2RAB9A | |
| SCHEMBL10197167 | 0.71 | DGAT1 (1.00) | DGAT1SOAT2RAB9A | |
| SCHEMBL10197738 | 0.71 | DGAT1 (1.00) | DGAT1SOAT2RAB9A | |
| SCHEMBL10198263 | 0.70 | DGAT1 (0.82) | DGAT1SOAT2CYP2C9 | |
| SCHEMBL10198260 | 0.70 | DGAT1 (0.82) | DGAT1SOAT2CYP2C9 | |
| SCHEMBL10197149 | 0.70 | DGAT1 (1.00) | DGAT1SOAT2CYP2C9 | |
| SCHEMBL384547 | 0.70 | DGAT1 (1.00) | DGAT1SOAT2CYP2C9 | |
| SCHEMBL384546 | 0.70 | DGAT1 (1.00) | DGAT1SOAT2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010107768-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |