Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.71 |
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.54 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611387 | 0.89 | TRPA1 (0.78) | TRPA1TRPV4TRPV3 | |
| SCHEMBL612545 | 0.87 | TRPA1 (0.71) | TRPA1TRPV4TRPV3 | |
| SCHEMBL612052 | 0.87 | TRPA1 (0.79) | TRPA1TRPV4 | |
| SCHEMBL612021 | 0.86 | TRPA1 (0.83) | TRPA1TRPV4 | |
| SCHEMBL609319 | 0.84 | TRPA1 (0.78) | TRPA1TRPV4TRPV3 | |
| SCHEMBL612025 | 0.84 | TRPA1 (0.75) | TRPA1TRPV4TRPV3 | |
| SCHEMBL612471 | 0.83 | TRPA1 (0.73) | TRPA1TRPV4TRPV3 | |
| SCHEMBL1802273 | 0.83 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL480954 | 0.83 | TRPA1 (0.88) | TRPA1TRPV4 | |
| SCHEMBL611669 | 0.82 | TRPA1 (0.76) | TRPA1TRPV4TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109287-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |