Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13191064 | 0.91 | LRRK2 (0.56) | LRRK2AURKAAURKBCLK2 | |
| SCHEMBL12826947 | 0.90 | LRRK2 (0.56) | LRRK2AURKAAURKBCLK1CLK2 | |
| SCHEMBL12826742 | 0.90 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL13191440 | 0.89 | LRRK2 (0.57) | LRRK2AURKAAURKB | |
| SCHEMBL13191065 | 0.89 | AURKA (0.56) | LRRK2AURKAAURKB | |
| SCHEMBL12826698 | 0.87 | LRRK2 (0.62) | LRRK2 | |
| SCHEMBL13191066 | 0.87 | PLK1 (0.55) | LRRK2AURKAAURKB | |
| SCHEMBL12826862 | 0.81 | LRRK2 (0.56) | LRRK2AURKAAURKB | |
| SCHEMBL12826701 | 0.81 | LRRK2 (0.60) | LRRK2 | |
| SCHEMBL1466072 | 0.80 | LRRK2 (0.60) | LRRK2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010106097-A1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | WO | disclosed |