Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
| ▸ | PLK1 | P53350 | 2/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.47 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826703 | 0.91 | LRRK2 (0.67) | AURKAAURKBLRRK2PTK2BRD4 | |
| SCHEMBL12826856 | 0.91 | AURKA (0.56) | AURKAAURKBLRRK2PTK2BRD4 | |
| SCHEMBL13191063 | 0.89 | LRRK2 (0.55) | AURKAAURKBLRRK2 | |
| SCHEMBL12826696 | 0.89 | LRRK2 (0.65) | AURKAAURKBLRRK2PTK2TTK | |
| SCHEMBL12826699 | 0.89 | LRRK2 (0.65) | AURKAAURKBLRRK2PTK2TTK | |
| SCHEMBL13191064 | 0.86 | LRRK2 (0.56) | AURKAAURKBLRRK2PTK2BRD4 | |
| SCHEMBL13191066 | 0.85 | PLK1 (0.55) | AURKAAURKBLRRK2PTK2BRD4 | |
| SCHEMBL13191440 | 0.85 | LRRK2 (0.57) | AURKAAURKBLRRK2PTK2TTK | |
| SCHEMBL16995435 | 0.81 | PTK2 (0.68) | AURKAAURKBLRRK2PTK2BRD4 | |
| SCHEMBL16995449 | 0.81 | PTK2 (0.57) | AURKAAURKBLRRK2PTK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010106097-A1 | SUBSTITUTED PYRIMIDINES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | WO | disclosed |