Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153134 | 0.82 | GLA (0.45) | PLGHTR2ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30406496 | 0.71 | HTR2A (0.42) | PLGHTR2ASLC6A3TRPA1ALDH1A1 | |
| SCHEMBL23115290 | 0.71 | HTR2A (0.42) | PLGHTR2ASLC6A3TRPA1ALDH1A1 | |
| SCHEMBL23115293 | 0.71 | HTR2A (0.42) | PLGHTR2ASLC6A3TRPA1ALDH1A1 | |
| SCHEMBL30406856 | 0.71 | HTR2A (0.42) | PLGHTR2ASLC6A3TRPA1ALDH1A1 | |
| SCHEMBL23222206 | 0.70 | PLG (0.48) | TAAR1PLGSLC6A3SLC6A2CHRM2 | |
| SCHEMBL13737199 | 0.68 | SLC22A1 (0.41) | — | |
| SCHEMBL10132275 | 0.68 | POLB (0.58) | PLGHTR2A | |
| SCHEMBL20828166 | 0.68 | POLB (0.58) | PLGHTR2A | |
| SCHEMBL3966432 | 0.67 | GBA1 (0.62) | PLGSLC6A3SLC6A2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010107605-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-09-23 | — | — | WO | disclosed |