Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10083311 | 0.81 | MAPT (0.56) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL3547238 | 0.78 | MAPT (0.49) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL18697150 | 0.72 | MAPT (0.47) | MAPTTDP1LMNAPOLBNPC1 | |
| SCHEMBL28000229 | 0.71 | KDM4E (0.54) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL19328487 | 0.71 | PDCD1 (0.40) | MAPTPDCD1CD274NPC1RAB9A | |
| SCHEMBL7901168 | 0.70 | HTT (0.40) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7893688 | 0.70 | ENPP2 (0.39) | MAPT | |
| SCHEMBL12066726 | 0.70 | EPHX2 (0.37) | MAPTLMNA | |
| SCHEMBL12031403 | 0.69 | PDCD1 (0.43) | MAPTKDM4EPDCD1CD274 | |
| SCHEMBL17805164 | 0.69 | EPHX2 (0.36) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012137089-A1 | PYRROLO [2, 3 -D] PYRIMIDINE DERIVATIVES AS INHIBITORS OF TROPOMYOSIN- RELATED KINASES | PFIZER LIMITED (GB) | 2012-10-11 | — | — | WO | disclosed |