Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.55 |
| ▸ | PRKDC | P78527 | 14/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.55 |
| ▸ | SRC | P12931 | 8/20 | 0.55 |
| ▸ | ABL1 | P00519 | 5/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | HCK | P08631 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | MTOR | P42345 | 3/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13198235 | 0.82 | PIK3CD (0.53) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2869270 | 0.81 | PIK3CD (0.44) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13198226 | 0.76 | SRC (0.49) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13198227 | 0.76 | PIK3CD (0.58) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13198236 | 0.76 | NPC1 (0.40) | ADORA2A | |
| SCHEMBL14074984 | 0.76 | SRC (0.51) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2863193 | 0.72 | MAPKAPK2 (0.46) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12551789 | 0.71 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14074983 | 0.70 | SRC (0.45) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13198228 | 0.70 | SRC (0.48) | PIK3CDPRKDCPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776890-B2 | 1H-indazole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-17 | — | — | US | disclosed |
| US-20090203691-A1 | Novel 1H-indazole compounds | OINUMA HITOSHI | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203691-A1 | Novel 1H-indazole compounds | MAPK1, MAPK3, MAPK13 | PIK3CD 2115/4885PRKDC 992/4885PIK3CA 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.