Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199028 | 0.92 | CCR2 (0.47) | CCR2KCNH2ROCK1MAPTHTT | |
| SCHEMBL13199037 | 0.90 | CCR2 (0.46) | CCR2KCNH2ROCK1HRH3MAPT | |
| SCHEMBL13199000 | 0.88 | CCR2 (0.44) | CCR2KCNH2ROCK1HRH3MAPT | |
| SCHEMBL13198980 | 0.87 | CCR2 (0.46) | CCR2KCNH2ROCK1HRH3MAPT | |
| SCHEMBL13199010 | 0.86 | CCR2 (0.45) | CCR2KCNH2ROCK1HRH3MAPT | |
| SCHEMBL13199021 | 0.86 | CCR2 (0.45) | CCR2KCNH2ROCK1HRH3MAPT | |
| SCHEMBL13199031 | 0.84 | CCR2 (0.46) | CCR2KCNH2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL13199005 | 0.84 | CCR2 (0.46) | CCR2KCNH2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL13199007 | 0.83 | CCR2 (0.45) | CCR2KCNH2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL13199038 | 0.82 | CCR2 (0.49) | CCR2KCNH2ROCK1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767681-B2 | 2-Carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-08-03 | — | — | US | disclosed |
| US-7767681-B2 | 2-Carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-08-03 | — | — | US | disclosed |