Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199041 | 0.93 | PDE5A (0.67) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL16267521 | 0.92 | PDE5A (0.71) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL5110534 | 0.89 | PDE5A (0.67) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL3071011 | 0.88 | PDE5A (0.74) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL5140293 | 0.84 | PDE5A (0.60) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL5116858 | 0.83 | PDE5A (0.71) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL27630149 | 0.82 | PDE5A (0.67) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL3071869 | 0.82 | PDE5A (0.77) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL6356567 | 0.82 | PDE5A (0.72) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL4849350 | 0.82 | PDE5A (1.00) | PDE5ACYP2D6CYP1A2CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767707-B2 | Fused pyrazolyl compounds having an aminoalkylcarbonyl group | YUNG SHIN PHARM. IND. CO., LTD. (TW) | 2010-08-03 | — | — | US | disclosed |
| US-7767707-B2 | Fused pyrazolyl compounds having an aminoalkylcarbonyl group | YUNG SHIN PHARM. IND. CO., LTD. (TW) | 2010-08-03 | — | — | US | disclosed |
| US-20090131681-A1 | Novel fused pyrazolyl compounds having an aminoalkylcarbonyl group | YUNG SHIN PHARM. IND. CO., LTD. (TW) | 2009-05-21 | — | — | US | disclosed |
| US-20090131681-A1 | Novel fused pyrazolyl compounds having an aminoalkylcarbonyl group | YUNG SHIN PHARM. IND. CO., LTD. (TW) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131681-A1 | Novel fused pyrazolyl compounds having an aminoalkylcarbonyl group | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCOR1, RB1 | PDE5A 4348/4885CYP2D6 1146/4885CYP1A2 2311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.