Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3071011 | 0.90 | PDE5A (0.74) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL27630150 | 0.89 | PDE5A (0.68) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL4849350 | 0.84 | PDE5A (1.00) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL5116858 | 0.83 | PDE5A (0.71) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL16267521 | 0.83 | PDE5A (0.71) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL13199036 | 0.82 | PDE5A (0.69) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL13618347 | 0.81 | PDE5A (0.71) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL5117785 | 0.81 | PDE5A (0.68) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL3073971 | 0.81 | PDE5A (0.85) | PDE5ACYP2D6KDM4EALDH1A1LMNA | |
| SCHEMBL5110534 | 0.81 | PDE5A (0.67) | PDE5ACYP2D6KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1680334-A | Fused pyrazolyls | YUNG SHIN PHARM IND CO LTD (CN) | 2005-10-12 | — | — | CN | claimed |
| EP-1586572-A1 | Fused pyrazolyls as anti-cancer drugs | Yung Shin Pharm. Ind. Co. Ltd. (TW) | 2005-10-19 | — | — | EP | disclosed |
| CN-1680334-A | Fused pyrazolyls | YUNG SHIN PHARM IND CO LTD (CN) | 2005-10-12 | — | — | CN | disclosed |