Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168749 | 0.74 | LMNA (0.43) | LMNAALDH1A1HPGDALPL | |
| SCHEMBL13799459 | 0.73 | LMNA (0.36) | LMNA | |
| SCHEMBL17482277 | 0.73 | LMNA (0.36) | LMNA | |
| SCHEMBL327787 | 0.73 | RECQL (0.38) | LMNARECQLALDH1A1HPGDALPL | |
| SCHEMBL2994350 | 0.71 | RECQL (0.37) | LMNARECQLALDH1A1HPGDALPL | |
| SCHEMBL4758990 | 0.69 | RECQL (0.39) | LMNARECQLALDH1A1ALPL | |
| SCHEMBL19113810 | 0.69 | RECQL (0.35) | LMNARECQLALDH1A1ALPL | |
| SCHEMBL5148878 | 0.69 | SMN1; SMN2 (0.33) | LMNA | |
| SCHEMBL11051607 | 0.69 | GAA (0.41) | LMNARECQLALDH1A1 | |
| SCHEMBL5147929 | 0.69 | LMNA (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767680-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-03 | — | — | US | disclosed |