Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KIF11 | P52732 | 7/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404298 | 0.91 | TP53 (0.43) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL14236421 | 0.91 | TP53 (0.43) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL764166 | 0.91 | TP53 (0.45) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL9962002 | 0.89 | LMNA (0.51) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL765012 | 0.89 | LMNA (0.51) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL8404306 | 0.89 | TP53 (0.46) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL9961998 | 0.89 | LMNA (0.51) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL765014 | 0.89 | TP53 (0.44) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL13199560 | 0.88 | LMNA (0.47) | LMNAMAPTTP53SMN1; SMN2KIF11 | |
| SCHEMBL9962076 | 0.88 | MAPT (0.48) | LMNAMAPTTP53SMN1; SMN2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767689-B2 | Carboline derivatives useful in the treatment of cancer | PTC THERAPEUTICS, INC. (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767689-B2 | Carboline derivatives useful in the treatment of cancer | PTC THERAPEUTICS, INC. (US) | 2010-08-03 | — | — | US | disclosed |