Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844672 | 0.89 | KMT2A (0.42) | KMT2ATSHRHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL2058770 | 0.87 | KMT2A (0.45) | KMT2ATSHRHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL4203152 | 0.87 | KMT2A (0.45) | KMT2ATSHRHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL12590876 | 0.87 | KMT2A (0.45) | KMT2ATSHRHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL12844216 | 0.84 | KMT2A (0.45) | KMT2ATSHRHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL12590875 | 0.82 | ABCB1 (0.49) | KMT2ATSHRHSD17B10TP53ALDH1A1 | |
| SCHEMBL10235503 | 0.82 | ABCB1 (0.49) | KMT2ATSHRHSD17B10TP53ALDH1A1 | |
| SCHEMBL12844671 | 0.78 | TRPA1 (0.44) | KMT2ATSHRHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL5784543 | 0.78 | SMN1; SMN2 (0.38) | KMT2ATSHRTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL2059010 | 0.75 | SMN1; SMN2 (0.38) | KMT2ATP53SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767687-B2 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors | BIOGEN IDEC MA INC. (US) | 2010-08-03 | — | — | US | disclosed |