Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13940212 | 0.94 | BACE1 (0.35) | AAK1BACE1 | |
| SCHEMBL13199839 | 0.82 | PDPK1 (0.32) | PDPK1 | |
| SCHEMBL31268069 | 0.81 | AAK1 (0.46) | AAK1BACE1PDPK1SSTR4USP30 | |
| SCHEMBL1958367 | 0.81 | AAK1 (0.46) | AAK1BACE1PDPK1SSTR4USP30 | |
| SCHEMBL31453237 | 0.80 | ALDH1A1 (0.40) | PDPK1USP30ALDH1A1 | |
| SCHEMBL13199693 | 0.78 | AAK1 (0.39) | AAK1BACE1PDPK1ALDH1A1 | |
| SCHEMBL29833741 | 0.78 | AAK1 (0.39) | AAK1BACE1PDPK1ALDH1A1 | |
| SCHEMBL10311298 | 0.78 | BACE1 (0.38) | AAK1BACE1PDPK1SSTR4USP30 | |
| SCHEMBL1958363 | 0.77 | AAK1 (0.41) | AAK1BACE1PDPK1SSTR4USP30 | |
| SCHEMBL404990 | 0.77 | BACE1 (0.39) | AAK1BACE1PDPK1SSTR4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772246-B2 | Pyrazole compounds as RAF inhibitors | PFIZER INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-7772246-B2 | Pyrazole compounds as RAF inhibitors | PFIZER INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20090221608-A1 | PYRAZOLE COMPOUNDS | PFIZER INC. | 2009-09-03 | — | — | US | disclosed |
| US-20090221608-A1 | PYRAZOLE COMPOUNDS | PFIZER INC. | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221608-A1 | PYRAZOLE COMPOUNDS | BRAF, RAF1, NRAS | AAK1 1551/4885BACE1 2706/4885PDPK1 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.