Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 7/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GLS | O94925 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234784 | 0.84 | MAPK14 (0.70) | FLT3RAF1MAPK14MEN1NPC1 | |
| SCHEMBL13200780 | 0.82 | FLT3 (0.63) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL13199933 | 0.82 | GAPDH (0.71) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL16943756 | 0.81 | EGFR (0.59) | RAF1EGFRMAPK14MEN1NPC1 | |
| SCHEMBL13199934 | 0.81 | KDM4E (0.71) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL13200037 | 0.81 | FLT3 (0.73) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL9978507 | 0.81 | FLT3 (0.62) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL1256800 | 0.81 | FLT3 (0.62) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL13200131 | 0.81 | FLT3 (0.60) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL13200041 | 0.80 | FLT3 (0.62) | FLT3RETNTRK1RAF1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |