Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.60 |
| ▸ | RAF1 | P04049 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200037 | 0.89 | FLT3 (0.73) | FLT3RAF1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL13234694 | 0.86 | FLT3 (0.77) | FLT3RAF1MEN1NPC1RAB9A | |
| SCHEMBL13200041 | 0.85 | FLT3 (0.62) | FLT3RAF1RETROCK1NTRK1 | |
| SCHEMBL31224659 | 0.85 | SMN1; SMN2 (0.67) | FLT3RAF1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL13200580 | 0.84 | FLT3 (0.72) | FLT3RAF1MEN1NPC1RAB9A | |
| SCHEMBL13200046 | 0.84 | FLT3 (0.76) | FLT3RAF1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13200615 | 0.83 | FLT3 (0.62) | FLT3RAF1RETNTRK1 | |
| SCHEMBL13200029 | 0.83 | FLT3 (0.55) | FLT3RAF1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL1256800 | 0.83 | FLT3 (0.62) | FLT3RAF1NPC1RAB9ARET | |
| SCHEMBL13200061 | 0.82 | FLT3 (0.61) | FLT3RAF1SMN1; SMN2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |