Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 9/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | GAPDH | P04406 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200383 | 0.89 | RET (0.62) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL9978507 | 0.87 | FLT3 (0.62) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL13200558 | 0.86 | RAF1 (0.59) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL13200780 | 0.86 | FLT3 (0.63) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL13199933 | 0.86 | GAPDH (0.71) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL1256800 | 0.85 | FLT3 (0.62) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL13200555 | 0.82 | FLT3 (0.73) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL13199934 | 0.82 | KDM4E (0.71) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL13200522 | 0.82 | FLT3 (0.69) | FLT3EGFRRETROCK1NTRK1 | |
| SCHEMBL13200580 | 0.82 | FLT3 (0.72) | FLT3EGFRRETROCK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |