Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.54 |
| ▸ | RET | P07949 | 6/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 4/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234843 | 0.88 | FLT3 (0.61) | FLT3RETCSF1RPDGFRBKIT | |
| SCHEMBL13200645 | 0.83 | FLT3 (0.54) | FLT3RETNTRK1CSF1RPDGFRB | |
| SCHEMBL13200432 | 0.82 | RAF1 (0.58) | FLT3RETNTRK1RAF1 | |
| SCHEMBL13200347 | 0.82 | FLT3 (0.52) | FLT3RETNTRK1EGFRRAF1 | |
| SCHEMBL12066000 | 0.81 | FLT3 (0.57) | FLT3RETCSF1RPDGFRBKIT | |
| SCHEMBL13200354 | 0.81 | RET (0.51) | FLT3RETNTRK1CSF1RPDGFRB | |
| SCHEMBL13200114 | 0.80 | FLT3 (0.58) | FLT3RETNTRK1CSF1RPDGFRB | |
| SCHEMBL13200343 | 0.79 | FLT3 (0.54) | FLT3RETNTRK1CSF1RPDGFRB | |
| SCHEMBL13200336 | 0.79 | FLT3 (0.52) | FLT3RETNTRK1RAF1ROCK1 | |
| SCHEMBL13200140 | 0.79 | FLT3 (0.60) | FLT3RETNTRK1EGFRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |