Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.58 |
| ▸ | FLT3 | P36888 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200336 | 0.86 | FLT3 (0.52) | RAF1FLT3MEN1KMT2ARET | |
| SCHEMBL13200645 | 0.84 | FLT3 (0.54) | RAF1FLT3MEN1KMT2ARET | |
| SCHEMBL13200358 | 0.84 | FLT3 (0.49) | RAF1FLT3MEN1KMT2ARET | |
| SCHEMBL13200354 | 0.82 | RET (0.51) | RAF1FLT3RETNTRK1 | |
| SCHEMBL13200347 | 0.82 | FLT3 (0.52) | RAF1FLT3RETNTRK1 | |
| SCHEMBL13200701 | 0.82 | FLT3 (0.54) | RAF1FLT3RETNTRK1 | |
| SCHEMBL13200037 | 0.80 | FLT3 (0.73) | RAF1FLT3MEN1KMT2ARET | |
| SCHEMBL13200025 | 0.80 | FLT3 (0.60) | RAF1FLT3MEN1KMT2ARET | |
| SCHEMBL13200343 | 0.78 | FLT3 (0.54) | RAF1FLT3MEN1KMT2ARET | |
| SCHEMBL13200166 | 0.77 | FLT3 (0.55) | RAF1FLT3MEN1KMT2ARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |