Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Hemisuccinate Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.84 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.84 |
| ▸ | TSHR | P16473 | 1/20 | 0.84 |
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | PGR | P06401 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.79 |
| ▸ | AR | P10275 | 2/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | FNTA | P49354 | 1/20 | 0.71 |
| ▸ | FNTB | P49356 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834722-B2 | Method of testing a gene therapy vector | BRUNEL UNIVERSITY LONDON (GB) | 2023-12-05 | — | — | US | disclosed |
| EP-3652347-B1 | METHOD OF TESTING A GENE THERAPY VECTOR | UNIV BRUNEL (GB) | 2023-05-03 | — | — | EP | disclosed |
| CN-114480253-B | Culture medium for directional induced differentiation of pluripotent stem cells into hepatocytes, culture method and application | 深圳市三启生物技术有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-114480495-A | Expression method and application of ALB fusion protein | 深圳市三启生物技术有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114480253-A | Culture medium for directional induced differentiation of pluripotent stem cells into hepatocytes, culture method and application | 深圳市三启生物技术有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20210130915-A1 | METHOD OF TESTING A GENE THERAPY VECTOR | BRUNEL UNIVERSITY LONDON (GB) | 2021-05-06 | — | — | US | disclosed |
| EP-3072507-B1 | PHARMACEUTICAL COMPOSITIONS FOR GLUCOCORTICOID REPLACEMENT THERAPY | SHIRE VIROPHARMA LLC (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3652347-A1 | METHOD OF TESTING A GENE THERAPY VECTOR | Brunel University London (GB) | 2020-05-20 | — | — | EP | disclosed |
| US-10583146-B2 | Pharmaceutical compositions for glucocorticoid replacement therapy | SHIRE VIROPHARMA INCORPORATED (US) | 2020-03-10 | — | — | US | disclosed |
| WO-2019012259-A1 | METHOD OF TESTING A GENE THERAPY VECTOR | BRUNEL UNIVERSITY LONDON (GB) | 2019-01-17 | — | — | WO | disclosed |
| EP-1744760-A2 | PHARMACEUTICAL COMPOSITIONS FOR ACUTE GLUCOCORTICOID THERAPY | Duocort AB (SE) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005102287-A2 | Pharmaceutical compositions for acute glucocorticoid therapy | DUOCORT AB (SE) | 2005-11-03 | — | — | WO | disclosed |
| WO-2005102271-A2 | PHARMACEUTICAL COMPOSITIONS FOR GLUCOCORTICOID REPLACEMENT THERAPY | DUOCORT AB (SE) | 2005-11-03 | — | — | WO | disclosed |
| US-6878747-B2 | Systemic formulations containing beta-carotene and derivatives thereof | BARANOWITZ STEVEN A (US) | 2005-04-12 | — | — | US | disclosed |
| EP-1084215-B1 | FRACTIONATION PROCESS | KARLSHAMNS AB (SE) | 2005-01-19 | — | — | EP | disclosed |
| US-20040068009-A1 | Systemic formulations containing beta-carotene and derivatives thereof | BARANOWITZ STEVEN A (US) | 2004-04-08 | — | — | US | disclosed |
| US-6552208-B1 | Separation of vegetable oils into confectionary fat and product enriched in unsaponifiables | KARLSHAMNS AB (SE) | 2003-04-22 | — | — | US | disclosed |
| WO-2002058586-A2 | SYSTEMIC FORMULATIONS CONTAINING BETA-CAROTENE AND DERIVATIVES THEREOF | BARANOWITZ STEVEN (US) | 2002-08-01 | — | — | WO | disclosed |
| EP-1084215-A1 | FRACTIONATION PROCESS | Karlshamns AB (SE) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063031-A1 | FRACTIONATION PROCESS | KARLSHAMNS AB (SE) | 1999-12-09 | — | — | WO | disclosed |