Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Hemisuccinate Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.84 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.84 |
| ▸ | TSHR | P16473 | 1/20 | 0.84 |
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | PGR | P06401 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.79 |
| ▸ | AR | P10275 | 2/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | FNTA | P49354 | 1/20 | 0.71 |
| ▸ | FNTB | P49356 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10182993-B2 | Compositions for colonic delivery of drugs | PATHEON SOFTGELS INC. (US) | 2019-01-22 | — | — | US | disclosed |
| EP-3086789-A1 | OPIOID ANTAGONIST FORMULATIONS | Purdue Pharma L.P. (US) | 2016-11-02 | — | — | EP | disclosed |
| US-20160287525-A1 | COMPOSITIONS FOR COLONIC DELIVERY OF DRUGS | BANNER LIFE SCIENCES LLC | 2016-10-06 | — | — | US | disclosed |
| US-20160243107-A1 | Opioid Antagonist Formulations | PURDUE PHARMA L.P. | 2016-08-25 | — | — | US | disclosed |
| WO-2015100197-A1 | OPIOID ANTAGONIST FORMULATIONS | PURDUE PHARMA L.P. (US) | 2015-07-02 | — | — | WO | disclosed |
| US-20100209520-A1 | ORAL PHARMACEUTICAL PREPARATION FOR COLON-SPECIFIC DELIVERY | AMATERASPHARMA INC. (JP) | 2010-08-19 | — | — | US | disclosed |
| EP-2143424-A1 | ORAL PHARMACEUTICAL PREPARATION FOR COLON-SPECIFIC DELIVERY | TEIKOKU SEIYAKU CO., LTD. (JP) | 2010-01-13 | — | — | EP | disclosed |