Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.64 |
| ▸ | APP | P05067 | 2/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | DCK | P27707 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4821816 | 0.81 | KDM1A (0.57) | KDM1AAPPCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL28911362 | 0.81 | KDM1A (0.57) | KDM1AAPPCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL13017787 | 0.81 | KDM1A (0.57) | KDM1AAPPCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL4014804 | 0.81 | KDM1A (0.57) | KDM1AAPPCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL4659871 | 0.79 | KDM1A (0.56) | KDM1AAPPCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL20924008 | 0.79 | KDM1A (0.70) | KDM1AAPPCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL526787 | 0.79 | KDM1A (1.00) | KDM1ACYP11B1CYP11B2 | |
| SCHEMBL15136122 | 0.79 | KDM1A (1.00) | KDM1ACYP11B1CYP11B2 | |
| SCHEMBL15136831 | 0.79 | KDM1A (1.00) | KDM1ACYP11B1CYP11B2 | |
| SCHEMBL12376481 | 0.78 | KDM1A (0.54) | KDM1AAPPCYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772256-B2 | 2-heteroaryl substituted benzothiophenes and benzofuranes 709 | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| US-7772256-B2 | 2-heteroaryl substituted benzothiophenes and benzofuranes 709 | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| EP-1539151-B1 | BIARYL COMPOUNDS HAVING ANTI-INFECTIVE ACTIVITY | GENESOFT PHARMACEUTICALS INC (US) | 2009-03-18 | — | — | EP | disclosed |
| US-7498349-B2 | Biaryl compounds having anti-infective activity | GENESOFT PHARMACEUTICALS, INC. (US) | 2009-03-03 | — | — | US | disclosed |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | PSEN1, APP, PSEN2 | KDM1A 3087/4885APP 2/4885CYP11B1 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.