Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398035 | 1.00 | MAPT (0.46) | MAPTDGAT1CA2CA12CA14 | |
| SCHEMBL17866134 | 0.86 | MAPT (0.40) | MAPTCA2CA12CA14TDP1 | |
| SCHEMBL8861814 | 0.86 | MAPT (0.40) | MAPTCA2CA12CA14TDP1 | |
| SCHEMBL1433275 | 0.86 | MAPT (0.40) | MAPTCA2CA12CA14TDP1 | |
| SCHEMBL12360947 | 0.84 | DGAT1 (0.42) | MAPTDGAT1CA2CA12CA14 | |
| SCHEMBL7395134 | 0.84 | DGAT1 (0.42) | MAPTDGAT1CA2CA12CA14 | |
| SCHEMBL13201422 | 0.81 | MAPT (0.43) | MAPTDGAT1CA2CA12CA14 | |
| SCHEMBL30805062 | 0.80 | MAPT (0.40) | MAPTDGAT1CA2CA12CA14 | |
| SCHEMBL23797446 | 0.80 | MAPT (0.42) | MAPTDGAT1CA2CA12CA14 | |
| SCHEMBL31730467 | 0.80 | MAPT (0.42) | MAPTDGAT1CA2CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767828-B2 | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |