Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201457 | 1.00 | CYP3A4 (0.50) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL13201417 | 1.00 | CYP3A4 (0.50) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL1992310 | 0.90 | CYP3A4 (0.57) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL9749110 | 0.85 | MAOA (0.56) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL5570751 | 0.85 | CYP3A4 (0.51) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL3889199 | 0.84 | OPRL1 (0.51) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL13201397 | 0.80 | CYP3A4 (0.53) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL17163357 | 0.80 | CYP3A4 (0.53) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| SCHEMBL950871 | 0.80 | CYP3A4 (0.53) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 | |
| Hydrochloric Acid SCHEMBL1036101 | 0.79 | CYP3A4 (0.51) | CYP3A4HSD17B10CYP2D6TSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767828-B2 | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767828-B2 | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576121-B2 | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV | PHENOMIX CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |