Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.77 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.75 |
| ▸ | MMP1 | P03956 | 1/20 | 0.75 |
| ▸ | MMP2 | P08253 | 1/20 | 0.75 |
| ▸ | MMP3 | P08254 | 1/20 | 0.75 |
| ▸ | MMP9 | P14780 | 1/20 | 0.75 |
| ▸ | MMP13 | P45452 | 1/20 | 0.75 |
| ▸ | TNF | P01375 | 11/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235406 | 1.00 | ADAM17 (0.77) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13200801 | 0.89 | TNF (0.78) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13200671 | 0.88 | ADAM17 (0.71) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13200654 | 0.88 | TNF (0.77) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL12862691 | 0.88 | TNF (0.77) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13200881 | 0.87 | TNF (0.76) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13889320 | 0.87 | ADAM17 (1.00) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13200797 | 0.87 | ADAM17 (1.00) | ADAM17ADAM10MMP1MMP2MMP3 | |
| SCHEMBL13200912 | 0.87 | ADAM17 (1.00) | ADAM17TNF | |
| SCHEMBL5956344 | 0.86 | ADAM17 (0.81) | ADAM17ADAM10MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772263-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2010-08-10 | — | — | US | disclosed |
| US-7772263-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2010-08-10 | — | — | US | disclosed |