Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL351070 | 0.95 | HSD11B1 (0.53) | HSD11B1CYP2D6 | |
| SCHEMBL1320863 | 0.89 | HSD11B1 (0.57) | HSD11B1CYP2D6 | |
| SCHEMBL350480 | 0.86 | HSD11B1 (0.76) | HSD11B1CYP2D6 | |
| SCHEMBL1322797 | 0.86 | HSD11B1 (0.73) | HSD11B1CYP2D6 | |
| SCHEMBL1320211 | 0.86 | HSD11B1 (0.59) | HSD11B1CYP2D6 | |
| SCHEMBL1320077 | 0.86 | HSD11B1 (0.59) | HSD11B1CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL350798 | 0.86 | HSD11B1 (0.51) | HSD11B1CYP2D6 | |
| SCHEMBL1320090 | 0.84 | HSD11B1 (0.51) | HSD11B1CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL349397 | 0.83 | HSD11B1 (0.54) | HSD11B1CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL351123 | 0.83 | HSD11B1 (0.65) | HSD11B1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9126927-B2 | Amido compounds and their use as pharmaceuticals | INCYTE HOLDINGS CORPORATION (US) | 2015-09-08 | — | — | US | claimed |
| EP-1756063-B1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-07-08 | — | — | EP | claimed |
| EP-1756063-B1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-07-08 | — | — | EP | disclosed |
| US-8058288-B2 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2011-11-15 | — | — | US | disclosed |
| US-7776874-B2 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2010-08-17 | — | — | US | disclosed |