Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.67 |
| ▸ | PIK3R2 | O00459 | 18/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.67 |
| ▸ | PIK3R5 | Q8WYR1 | 18/20 | 0.67 |
| ▸ | PIK3R3 | Q92569 | 18/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13328 | 0.87 | PIK3CD (0.61) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13267 | 0.85 | PIK3CD (0.61) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13199 | 0.85 | PIK3CD (0.64) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12505 | 0.81 | PIK3CD (0.67) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7173 | 0.80 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13277 | 0.80 | PIK3CD (0.63) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13111 | 0.80 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082778 | 0.79 | PIK3CD (0.47) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082804 | 0.79 | PIK3CD (0.61) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12617 | 0.77 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |