Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.68 |
| ▸ | PIK3R2 | O00459 | 19/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.68 |
| ▸ | PIK3R5 | Q8WYR1 | 19/20 | 0.68 |
| ▸ | PIK3R3 | Q92569 | 19/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13277 | 0.92 | PIK3CD (0.63) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13148 | 0.88 | PIK3CD (0.60) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082820 | 0.86 | PIK3CD (0.50) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13372 | 0.85 | PIK3CD (0.57) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12505 | 0.83 | PIK3CD (0.67) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7738 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13204 | 0.80 | PIK3CD (0.67) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082811 | 0.78 | RAB9A (0.48) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7619 | 0.77 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13328 | 0.76 | PIK3CD (0.61) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |