Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.30 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1320565 | 1.00 | ALDH1A1 (0.46) | ALDH1A1TDP1CA2STAT3KISS1R | |
| SCHEMBL2220485 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TDP1CA2STAT3KISS1R | |
| SCHEMBL11511816 | 0.78 | ALDH1A1 (0.48) | ALDH1A1TDP1CA2STAT3KISS1R | |
| SCHEMBL11511817 | 0.78 | ALDH1A1 (0.48) | ALDH1A1TDP1CA2STAT3KISS1R | |
| SCHEMBL1320949 | 0.77 | CA1 (0.43) | ALDH1A1TDP1 | |
| SCHEMBL1320950 | 0.77 | CA1 (0.43) | ALDH1A1TDP1 | |
| SCHEMBL16642030 | 0.73 | TDP1 (0.42) | ALDH1A1TDP1CA2STAT3CACNA2D1 | |
| SCHEMBL8812729 | 0.73 | ALDH1A1 (0.42) | ALDH1A1TDP1CA2STAT3KISS1R | |
| SCHEMBL20384963 | 0.73 | ALDH1A1 (0.42) | ALDH1A1TDP1CA2STAT3KISS1R | |
| SCHEMBL11018655 | 0.73 | ALDH1A1 (0.42) | ALDH1A1TDP1CA2STAT3KISS1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058447-B2 | 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-15 | — | — | US | disclosed |
| US-8058447-B2 | 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-15 | — | — | US | disclosed |
| US-8058447-B2 | 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-15 | — | — | US | disclosed |
| EP-1926727-B1 | 4-CHROMENONYL-1,4-DIHYDROPYRIDINECARBONITRILES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2011-09-14 | — | — | EP | disclosed |
| US-7989633-B2 | 4-Chromenonyl-1,4-dihydropyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-02 | — | — | US | disclosed |
| US-7989633-B2 | 4-Chromenonyl-1,4-dihydropyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-02 | — | — | US | disclosed |
| US-7989633-B2 | 4-Chromenonyl-1,4-dihydropyridines and their use | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-02 | — | — | US | disclosed |
| US-20100022484-A1 | 4-Chromenonyl-1,4-dihydropyridines and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20100022484-A1 | 4-Chromenonyl-1,4-dihydropyridines and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20100022484-A1 | 4-Chromenonyl-1,4-dihydropyridines and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20090214675-A1 | 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof | BAYER HEALTHCARE AG (DE) | 2009-08-27 | — | — | US | disclosed |
| US-20090214675-A1 | 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof | BAYER HEALTHCARE AG (DE) | 2009-08-27 | — | — | US | disclosed |
| US-20090214675-A1 | 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof | BAYER HEALTHCARE AG (DE) | 2009-08-27 | — | — | US | disclosed |
| EP-1926727-A1 | 4-CHROMENONYL-1,4-DIHYDROPYRIDINECARBONITRILES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2008-06-04 | — | — | EP | disclosed |
| EP-1910329-A1 | 4-CHROMENONYL-1,4-DIHYDROPYRIDINES AND THEIR USE | Bayer HealthCare AG (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007025604-A1 | 4-CHROMENONYL-1,4-DIHYDROPYRIDINES AND THEIR USE | BAYER HEALTHCARE AG (DE) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025604-A1 | 4-CHROMENONYL-1,4-DIHYDROPYRIDINES AND THEIR USE | BAYER HEALTHCARE AG (DE) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007009670-A1 | 4-CHROMENONYL-1,4-DIHYDROPYRIDINECARBONITRILES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2007009670-A1 | 4-CHROMENONYL-1,4-DIHYDROPYRIDINECARBONITRILES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2005087740-A1 | FLUORENONE 1, 4,-DIHYDROPYRIDIN DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022484-A1 | 4-Chromenonyl-1,4-dihydropyridines and their use | RYR1, RYR2, CACNA1S | ALDH1A1 542/4885TDP1 536/4885CA2 640/4885 |
| US-20090214675-A1 | 4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof | RYR1, TNNI3, RYR2 | ALDH1A1 323/4885TDP1 533/4885CA2 1725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.