Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13209323 | 1.00 | GCK (0.42) | GCKRARARARBGRM5RARG | |
| SCHEMBL13209318 | 0.89 | GCK (0.34) | GCK | |
| SCHEMBL2666549 | 0.88 | GCK (0.38) | GCK | |
| SCHEMBL13209552 | 0.86 | GCK (0.38) | GCKRARARARBGRM5RARG | |
| SCHEMBL13209325 | 0.85 | GCK (0.51) | GCKRARARARBRARG | |
| SCHEMBL2667101 | 0.84 | GCK (0.40) | GCKRARARARBGRM5RARG | |
| SCHEMBL13209586 | 0.83 | GCK (0.51) | GCKRARARARBRARG | |
| SCHEMBL2669305 | 0.83 | GCK (0.32) | GCK | |
| SCHEMBL9072514 | 0.82 | GCK (0.47) | GCKRARG | |
| SCHEMBL2666255 | 0.82 | GCK (0.49) | GCKRARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756076-B1 | HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2010-08-11 | — | — | EP | disclosed |