Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988572 | 0.80 | CHRM5 (0.48) | CHRM5ADRA2CACHESMN1; SMN2JAK2 | |
| SCHEMBL1442390 | 0.79 | CHRM5 (0.35) | CHRM5ADRA2CACHESMN1; SMN2KCNA3 | |
| SCHEMBL1442388 | 0.79 | CHRM5 (0.35) | CHRM5ADRA2CACHESMN1; SMN2KCNA3 | |
| Hydrochloric Acid SCHEMBL11558196 | 0.78 | CHRM5 (0.46) | CHRM5ADRA2CACHESMN1; SMN2KDM4E | |
| SCHEMBL10217085 | 0.75 | ACHE (0.36) | CHRM5ADRA2CACHESMN1; SMN2KCNA3 | |
| SCHEMBL9598465 | 0.74 | CHRM5 (0.67) | CHRM5ADRA2CACHESMN1; SMN2 | |
| SCHEMBL9906606 | 0.74 | CHRM5 (0.60) | CHRM5ADRA2CACHESMN1; SMN2KCNA3 | |
| SCHEMBL9906605 | 0.73 | CYP2A13 (0.41) | CHRM5ADRA2CACHESMN1; SMN2KDM4E | |
| SCHEMBL9906604 | 0.73 | KDM4E (0.47) | CHRM5ADRA2CACHEKDM4EALDH1A1 | |
| SCHEMBL25571664 | 0.72 | CHRM5 (0.37) | CHRM5ADRA2CACHESMN1; SMN2KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786308-B2 | Muscarinic modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-31 | — | — | US | disclosed |