Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698955 | 0.81 | POLB (0.52) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL30274454 | 0.81 | POLB (0.52) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL596646 | 0.81 | POLB (0.57) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL6403911 | 0.79 | POLB (0.50) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL8850092 | 0.79 | GABRA1 (0.52) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL8904831 | 0.79 | POLB (0.50) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL30640504 | 0.79 | GABRA1 (0.52) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL16414608 | 0.79 | POLB (0.50) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL14176963 | 0.79 | POLB (0.50) | POLBALDH1A1HSD17B10CYP2A6TSHR | |
| SCHEMBL12807315 | 0.78 | HSD17B10 (0.48) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836201-B1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH INC (US) | 2010-08-11 | — | — | EP | disclosed |