Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 7/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.31 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953944 | 0.90 | BRAF (0.46) | ACVR1BRAFDYRK1BMAP3K14 | |
| SCHEMBL13939830 | 0.86 | DYRK1B (0.41) | ACVR1BRAFDYRK1BMAP3K14MKNK1 | |
| SCHEMBL2959526 | 0.81 | BRAF (0.45) | ACVR1BRAFDYRK1BMAP3K14 | |
| SCHEMBL2962021 | 0.72 | LMNA (0.40) | ACVR1DYRK1B | |
| SCHEMBL2640156 | 0.71 | ACVR1 (0.47) | ACVR1BRAFMAP3K14 | |
| SCHEMBL2959275 | 0.70 | DYRK1A (0.36) | ACVR1BRAFDYRK1B | |
| SCHEMBL8228196 | 0.70 | BRAF (0.57) | BRAF | |
| SCHEMBL13200107 | 0.69 | BRAF (0.44) | ACVR1BRAFMAP3K14 | |
| SCHEMBL2961902 | 0.68 | BRAF (0.46) | ACVR1BRAFMAP3K14 | |
| SCHEMBL2639988 | 0.68 | BRAF (0.44) | ACVR1BRAFMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772246-B2 | Pyrazole compounds as RAF inhibitors | PFIZER INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20090221608-A1 | PYRAZOLE COMPOUNDS | PFIZER INC. | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221608-A1 | PYRAZOLE COMPOUNDS | BRAF, RAF1, NRAS | ACVR1 4191/4885BRAF 1/4885DYRK1B 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.