Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 4/20 | 0.33 |
| ▸ | FDPS | P14324 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451668 | 0.80 | SMPD1 (0.46) | SMPD1FDPS | |
| SCHEMBL13960421 | 0.80 | SMPD1 (0.46) | SMPD1FDPS | |
| SCHEMBL10397620 | 0.80 | SMPD1 (0.46) | SMPD1FDPS | |
| SCHEMBL13120065 | 0.80 | SMPD1 (0.46) | SMPD1FDPS | |
| SCHEMBL11042226 | 0.78 | SMPD1 (0.48) | SMPD1FDPS | |
| SCHEMBL10608827 | 0.78 | SMPD1 (0.48) | SMPD1FDPS | |
| SCHEMBL9846062 | 0.78 | SMPD1 (0.48) | SMPD1FDPS | |
| SCHEMBL22703594 | 0.78 | FDPS (0.44) | SMPD1FDPS | |
| SCHEMBL8536232 | 0.78 | SMPD1 (0.48) | SMPD1FDPS | |
| SCHEMBL18462070 | 0.78 | FDPS (0.44) | SMPD1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776869-B2 | Heteroaryl-substituted alkyne compounds and method of use | AMGEN INC. (US) | 2010-08-17 | — | — | US | disclosed |