Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KISS1R | Q969F8 | 4/20 | 0.42 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2979203 | 0.87 | TP53 (0.45) | KISS1RTP53MAPT | |
| SCHEMBL2979166 | 0.84 | FYN (0.43) | KISS1RSMYD2TP53MAPT | |
| SCHEMBL2976622 | 0.84 | TP53 (0.47) | SMYD2TP53KCNA3MAPT | |
| SCHEMBL2976493 | 0.83 | TP53 (0.44) | KISS1RHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL2972727 | 0.82 | MAPT (0.47) | TP53MAPT | |
| SCHEMBL2966548 | 0.82 | TP53BP1 (0.53) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL2969680 | 0.82 | CDK4 (0.50) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL2977071 | 0.82 | ALDH1A1 (0.53) | TP53MAPT | |
| SCHEMBL2971414 | 0.81 | KCNH2 (0.49) | TP53KCNA3MAPT | |
| SCHEMBL2978922 | 0.81 | LIMK1 (0.40) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776847-B2 | Benzisothiazoles useful for treating or preventing HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2010-08-17 | — | — | US | disclosed |